Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells.

Protein kinase CK2 is frequently elevated in a variety of human cancers. The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance, and its aberrant activation has been indicated in several types of cancer, including lung cancer. In this study, we show that CK2 is positively i...

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Autores principales: Shulin Zhang, Yucheng Wang, Jian-Hua Mao, David Hsieh, Il-Jin Kim, Li-Min Hu, Zhidong Xu, Hao Long, David M Jablons, Liang You
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/e540428714c245059c3c4feaac0279b0
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