Docosahexaenoic Acid and Eicosapentaenoic Acid Intakes Modulate the Association of <i>FADS2</i> Gene Polymorphism rs526126 with Plasma Free Docosahexaenoic Acid Levels in Overweight Children

Docosahexaenoic Acid and Eicosapentaenoic Acid Intakes Modulate the Association of <i>FADS2</i> Gene Polymorphism rs526126 with Plasma Free Docosahexaenoic Acid Levels in Overweight Children

Polyunsaturated fatty acids are involved in a wide variety of biological functions. Linoleic acid and alpha-linolenic acid are two essential fatty acids that the body cannot synthesize. The conversion rates in the body depend on <i>FADS2</i> genetic variants. Certain variations in this g...

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Autores principales: Alexandra Mihailescu, Vlad Serafim, Corina Paul, Nicoleta Andreescu, Diana-Andreea Tiugan, Paul Tutac, Iulian Velea, Cristian G. Zimbru, Costela Lacrimioara Serban, Adina Iuliana Ion, Vlad Laurentiu David, Alin Ionescu, Maria Puiu, Mihai Dinu Niculescu
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
long chain polyunsaturated fatty acids (LC-PUFAs)
<i>FADS2</i> gene
pediatric obesity
dietary intake
Technology
T
Engineering (General). Civil engineering (General)
TA1-2040
Biology (General)
QH301-705.5
Physics
QC1-999
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/e5418b276a28412aac556d54b9dc28c9
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Sumario:Polyunsaturated fatty acids are involved in a wide variety of biological functions. Linoleic acid and alpha-linolenic acid are two essential fatty acids that the body cannot synthesize. The conversion rates in the body depend on <i>FADS2</i> genetic variants. Certain variations in this gene are directly responsible for the low levels and poor conversion efficiency of the delta-6 desaturase enzyme, resulting in low circulating levels of docosahexaenoic acid. In this study, we evaluated the impact of the rs526126 <i>FADS2</i> gene polymorphism on fatty acid levels in a group of two hundred children (<i>n</i> = 95 males, <i>n</i> = 105 females) aged 7–18 years, with obesity defined by BMI > +2 SD. Fatty acid quantification was performed by LC-MS/MS while genotyping for genetic variants was performed using a custom-made hotspot sequencing panel of 55 SNPs. Our results suggest that rs526126 <i>FADS2</i> gene polymorphism specifically impacts the plasma levels of free n-3 polyunsaturated fatty acids. Finally, the presence of the minor allele G of rs526126 could have beneficial effects, as it was associated with higher levels of free docosahexaenoic acid in plasma, especially in children with low n-3 intakes.

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