Reduced oxidative capacity in macrophages results in systemic insulin resistance

M1-like polarization of macrophages is thought to control adipose inflammation and associated insulin resistance and metabolic syndrome. Here the authors show that macrophage-specific deletion of the OxPhos-related gene Crif1 results in an M1-like phenotype in mice, and that the effects can be rever...

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Autores principales:	Saet-Byel Jung, Min Jeong Choi, Dongryeol Ryu, Hyon-Seung Yi, Seong Eun Lee, Joon Young Chang, Hyo Kyun Chung, Yong Kyung Kim, Seul Gi Kang, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Cuk-Seong Kim, Chul-Ho Lee, Robert W. Williams, Hail Kim, Heung Kyu Lee, Johan Auwerx, Minho Shong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e543088fca854de18576144178eee3f2
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spelling	oai:doaj.org-article:e543088fca854de18576144178eee3f22021-12-02T16:50:04ZReduced oxidative capacity in macrophages results in systemic insulin resistance10.1038/s41467-018-03998-z2041-1723https://doaj.org/article/e543088fca854de18576144178eee3f22018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03998-zhttps://doaj.org/toc/2041-1723M1-like polarization of macrophages is thought to control adipose inflammation and associated insulin resistance and metabolic syndrome. Here the authors show that macrophage-specific deletion of the OxPhos-related gene Crif1 results in an M1-like phenotype in mice, and that the effects can be reversed by recombinant GDF15.Saet-Byel JungMin Jeong ChoiDongryeol RyuHyon-Seung YiSeong Eun LeeJoon Young ChangHyo Kyun ChungYong Kyung KimSeul Gi KangJu Hee LeeKoon Soon KimHyun Jin KimCuk-Seong KimChul-Ho LeeRobert W. WilliamsHail KimHeung Kyu LeeJohan AuwerxMinho ShongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saet-Byel Jung Min Jeong Choi Dongryeol Ryu Hyon-Seung Yi Seong Eun Lee Joon Young Chang Hyo Kyun Chung Yong Kyung Kim Seul Gi Kang Ju Hee Lee Koon Soon Kim Hyun Jin Kim Cuk-Seong Kim Chul-Ho Lee Robert W. Williams Hail Kim Heung Kyu Lee Johan Auwerx Minho Shong Reduced oxidative capacity in macrophages results in systemic insulin resistance
description	M1-like polarization of macrophages is thought to control adipose inflammation and associated insulin resistance and metabolic syndrome. Here the authors show that macrophage-specific deletion of the OxPhos-related gene Crif1 results in an M1-like phenotype in mice, and that the effects can be reversed by recombinant GDF15.
format	article
author	Saet-Byel Jung Min Jeong Choi Dongryeol Ryu Hyon-Seung Yi Seong Eun Lee Joon Young Chang Hyo Kyun Chung Yong Kyung Kim Seul Gi Kang Ju Hee Lee Koon Soon Kim Hyun Jin Kim Cuk-Seong Kim Chul-Ho Lee Robert W. Williams Hail Kim Heung Kyu Lee Johan Auwerx Minho Shong
author_facet	Saet-Byel Jung Min Jeong Choi Dongryeol Ryu Hyon-Seung Yi Seong Eun Lee Joon Young Chang Hyo Kyun Chung Yong Kyung Kim Seul Gi Kang Ju Hee Lee Koon Soon Kim Hyun Jin Kim Cuk-Seong Kim Chul-Ho Lee Robert W. Williams Hail Kim Heung Kyu Lee Johan Auwerx Minho Shong
author_sort	Saet-Byel Jung
title	Reduced oxidative capacity in macrophages results in systemic insulin resistance
title_short	Reduced oxidative capacity in macrophages results in systemic insulin resistance
title_full	Reduced oxidative capacity in macrophages results in systemic insulin resistance
title_fullStr	Reduced oxidative capacity in macrophages results in systemic insulin resistance
title_full_unstemmed	Reduced oxidative capacity in macrophages results in systemic insulin resistance
title_sort	reduced oxidative capacity in macrophages results in systemic insulin resistance
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e543088fca854de18576144178eee3f2
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Reduced oxidative capacity in macrophages results in systemic insulin resistance

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