Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery

Diketopiperazine derivatives are bioactive molecules with scaffold formed by the condensation of two amino acids. Here, Yao et al. mine the genomes of Streptomyces strains and identify new biosynthetic machinery for drimentines biosynthesis, which includes cyclodipeptide synthase, prenyltransferase,...

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Auteurs principaux: Tingting Yao, Jing Liu, Zengzhi Liu, Tong Li, Huayue Li, Qian Che, Tianjiao Zhu, Dehai Li, Qianqun Gu, Wenli Li
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/e546f0a9c8004b52ba5bf6cf5e299ecd
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