Molecular snapshots of APE1 proofreading mismatches and removing DNA damage

The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.

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Autores principales: Amy M. Whitaker, Tony S. Flynn, Bret D. Freudenthal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be9381
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