Molecular snapshots of APE1 proofreading mismatches and removing DNA damage

The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.

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Autores principales: Amy M. Whitaker, Tony S. Flynn, Bret D. Freudenthal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be9381
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spelling oai:doaj.org-article:e5519c6bbf5142a09fe7a58d28be93812021-12-02T15:33:59ZMolecular snapshots of APE1 proofreading mismatches and removing DNA damage10.1038/s41467-017-02175-y2041-1723https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be93812018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02175-yhttps://doaj.org/toc/2041-1723The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.Amy M. WhitakerTony S. FlynnBret D. FreudenthalNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Amy M. Whitaker
Tony S. Flynn
Bret D. Freudenthal
Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
description The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.
format article
author Amy M. Whitaker
Tony S. Flynn
Bret D. Freudenthal
author_facet Amy M. Whitaker
Tony S. Flynn
Bret D. Freudenthal
author_sort Amy M. Whitaker
title Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
title_short Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
title_full Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
title_fullStr Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
title_full_unstemmed Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
title_sort molecular snapshots of ape1 proofreading mismatches and removing dna damage
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be9381
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