Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.
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Nature Portfolio
2018
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oai:doaj.org-article:e5519c6bbf5142a09fe7a58d28be93812021-12-02T15:33:59ZMolecular snapshots of APE1 proofreading mismatches and removing DNA damage10.1038/s41467-017-02175-y2041-1723https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be93812018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02175-yhttps://doaj.org/toc/2041-1723The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.Amy M. WhitakerTony S. FlynnBret D. FreudenthalNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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Science Q Amy M. Whitaker Tony S. Flynn Bret D. Freudenthal Molecular snapshots of APE1 proofreading mismatches and removing DNA damage |
description |
The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism. |
format |
article |
author |
Amy M. Whitaker Tony S. Flynn Bret D. Freudenthal |
author_facet |
Amy M. Whitaker Tony S. Flynn Bret D. Freudenthal |
author_sort |
Amy M. Whitaker |
title |
Molecular snapshots of APE1 proofreading mismatches and removing DNA damage |
title_short |
Molecular snapshots of APE1 proofreading mismatches and removing DNA damage |
title_full |
Molecular snapshots of APE1 proofreading mismatches and removing DNA damage |
title_fullStr |
Molecular snapshots of APE1 proofreading mismatches and removing DNA damage |
title_full_unstemmed |
Molecular snapshots of APE1 proofreading mismatches and removing DNA damage |
title_sort |
molecular snapshots of ape1 proofreading mismatches and removing dna damage |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be9381 |
work_keys_str_mv |
AT amymwhitaker molecularsnapshotsofape1proofreadingmismatchesandremovingdnadamage AT tonysflynn molecularsnapshotsofape1proofreadingmismatchesandremovingdnadamage AT bretdfreudenthal molecularsnapshotsofape1proofreadingmismatchesandremovingdnadamage |
_version_ |
1718386997822750720 |