Molecular snapshots of APE1 proofreading mismatches and removing DNA damage

The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.

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Auteurs principaux:	Amy M. Whitaker, Tony S. Flynn, Bret D. Freudenthal
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be9381
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id	oai:doaj.org-article:e5519c6bbf5142a09fe7a58d28be9381
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spelling	oai:doaj.org-article:e5519c6bbf5142a09fe7a58d28be93812021-12-02T15:33:59ZMolecular snapshots of APE1 proofreading mismatches and removing DNA damage10.1038/s41467-017-02175-y2041-1723https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be93812018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02175-yhttps://doaj.org/toc/2041-1723The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.Amy M. WhitakerTony S. FlynnBret D. FreudenthalNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy M. Whitaker Tony S. Flynn Bret D. Freudenthal Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
description	The essential DNA repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) has both endonuclease and exonuclease activities. Here, the authors present DNA bound human APE1 crystal structures which give insights into its exonuclease mechanism.
format	article
author	Amy M. Whitaker Tony S. Flynn Bret D. Freudenthal
author_facet	Amy M. Whitaker Tony S. Flynn Bret D. Freudenthal
author_sort	Amy M. Whitaker
title	Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
title_short	Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
title_full	Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
title_fullStr	Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
title_full_unstemmed	Molecular snapshots of APE1 proofreading mismatches and removing DNA damage
title_sort	molecular snapshots of ape1 proofreading mismatches and removing dna damage
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e5519c6bbf5142a09fe7a58d28be9381
work_keys_str_mv	AT amymwhitaker molecularsnapshotsofape1proofreadingmismatchesandremovingdnadamage AT tonysflynn molecularsnapshotsofape1proofreadingmismatchesandremovingdnadamage AT bretdfreudenthal molecularsnapshotsofape1proofreadingmismatchesandremovingdnadamage
_version_	1718386997822750720

Molecular snapshots of APE1 proofreading mismatches and removing DNA damage

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