Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
Perivascular cells are essential to the formation and stabilization of new blood vessels during angiogenesis. Here, Hess and Kelly-Goss et al. show that the stem cell pluripotency factor Oct4 promotes perivascular cell survival and migration required for angiogenesis in contexts of tissue injury and...
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Main Authors: | Daniel L. Hess, Molly R. Kelly-Goss, Olga A. Cherepanova, Anh T. Nguyen, Richard A. Baylis, Svyatoslav Tkachenko, Brian H. Annex, Shayn M. Peirce, Gary K. Owens |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2019
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Subjects: | |
Online Access: | https://doaj.org/article/e55a3bf1dfe040a6ab7dfaf6ab1c2344 |
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