Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1

Abstract A non-canonical PRC1 (PRC1.6) prevents precocious meiotic onset. Germ cells alleviate its negative effect by reducing their amount of MAX, a component of PRC1.6, as a prerequisite for their bona fide meiosis. Here, we found that germ cells produced Mga variant mRNA bearing a premature termi...

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Autores principales: Yuka Kitamura, Kousuke Uranishi, Masataka Hirasaki, Masazumi Nishimoto, Ayumu Suzuki, Akihiko Okuda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e5725950dfaa4ffa90fb9e62a661d97f
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