Septal chondrocyte hypertrophy contributes to midface deformity in a mouse model of Apert syndrome
Abstract Midface hypoplasia is a major manifestation of Apert syndrome. However, the tissue component responsible for midface hypoplasia has not been elucidated. We studied mice with a chondrocyte-specific Fgfr2 S252W mutation (Col2a1-cre; Fgfr2 S252W/+) to investigate the effect of cartilaginous co...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2021
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| Accès en ligne: | https://doaj.org/article/e581febabd234dd09e9937a0b26d6e38 |
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