Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys

Introduction: In most ancient cultures, honey has been used for both nutritional and medical purposes. Objectives: In this research, phenolic extracts of four Iranian honeys were evaluated to determine the antioxidant potentials using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, nitric o...

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Autores principales:	Mahmoodreza Moein, Soheila Moein, Fatemeh Farmani, Sahere Rozbehan, Zahra Sabahi
Formato:	article
Lenguaje:	EN
Publicado:	Society of Diabetic Nephropathy Prevention 2022
Materias:	antioxidant activity α-amylase inhibition α-glucosidase inhibition iranian honey radical scavenging Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/e585057b5b4b4804bde6bb85d0912446
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spelling	oai:doaj.org-article:e585057b5b4b4804bde6bb85d09124462021-11-17T08:15:00ZExamination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys2345-420210.34172/npj.2022.06https://doaj.org/article/e585057b5b4b4804bde6bb85d09124462022-01-01T00:00:00Zhttps://jnephropharmacology.com/PDF/npj-10441https://doaj.org/toc/2345-4202Introduction: In most ancient cultures, honey has been used for both nutritional and medical purposes. Objectives: In this research, phenolic extracts of four Iranian honeys were evaluated to determine the antioxidant potentials using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, nitric oxide (NO) radical scavenging and reducing power by ferric reducing activity of plasma (FRAP) method. Additionally, anti-diabetic properties of honey and phenolic extracts were evaluated by determination of α-amylase and α-glucosidase inhibition. Patients and Methods: Besides, reducing potential was evaluated by ferric-reducing antioxidant power method. Moreover, determination of phenolic and flavonoid contents was performed. Moreover, inhibition of α-amylase and α-glucosidase of honey and phenolic extracts were evaluated. Results: With considering to antioxidant potentials, Gavan (Astragalus) sample showed the greatest phenolic (3817±1.52 mg GAE/100 g), flavonoid contents (3.1±0.005 mg QE/100 g), and DPPH radical scavenging (IC50 = 2±0.003 mg/mL). Bahareh honey had the highest NO radical scavenging (IC50=0.0403±0.0009 mg/mL) and Meymand honey possessed the highest reducing potential by FRAP method (IC50=0.0018±0.000003 mg/mL). The maximum inhibition of α-glucosidase was shown in Meymand honey extract (46±0.1%). After sugar isolation, Zataria honey had the highest inhibition of α-glucosidase (54±0.6%) and the mode of α-amylase inhibition was noncompetitive by this honey. Whole extract (23±0.1%) and phenolic extract of Gavan honey presented the maximum inhibition of α-amylase (31.2±0.1%). Conclusion: Honey samples showed antioxidant potentials and anti-diabetic properties by retardation of α-amylase and α-glucosidase.Mahmoodreza MoeinSoheila MoeinFatemeh FarmaniSahere RozbehanZahra SabahiSociety of Diabetic Nephropathy Prevention articleantioxidant activityα-amylase inhibitionα-glucosidase inhibitioniranian honeyradical scavengingTherapeutics. PharmacologyRM1-950Diseases of the genitourinary system. UrologyRC870-923ENJournal of Nephropharmacology, Vol 11, Iss 1, Pp e6-e6 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant activity α-amylase inhibition α-glucosidase inhibition iranian honey radical scavenging Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923
spellingShingle	antioxidant activity α-amylase inhibition α-glucosidase inhibition iranian honey radical scavenging Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923 Mahmoodreza Moein Soheila Moein Fatemeh Farmani Sahere Rozbehan Zahra Sabahi Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys
description	Introduction: In most ancient cultures, honey has been used for both nutritional and medical purposes. Objectives: In this research, phenolic extracts of four Iranian honeys were evaluated to determine the antioxidant potentials using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, nitric oxide (NO) radical scavenging and reducing power by ferric reducing activity of plasma (FRAP) method. Additionally, anti-diabetic properties of honey and phenolic extracts were evaluated by determination of α-amylase and α-glucosidase inhibition. Patients and Methods: Besides, reducing potential was evaluated by ferric-reducing antioxidant power method. Moreover, determination of phenolic and flavonoid contents was performed. Moreover, inhibition of α-amylase and α-glucosidase of honey and phenolic extracts were evaluated. Results: With considering to antioxidant potentials, Gavan (Astragalus) sample showed the greatest phenolic (3817±1.52 mg GAE/100 g), flavonoid contents (3.1±0.005 mg QE/100 g), and DPPH radical scavenging (IC50 = 2±0.003 mg/mL). Bahareh honey had the highest NO radical scavenging (IC50=0.0403±0.0009 mg/mL) and Meymand honey possessed the highest reducing potential by FRAP method (IC50=0.0018±0.000003 mg/mL). The maximum inhibition of α-glucosidase was shown in Meymand honey extract (46±0.1%). After sugar isolation, Zataria honey had the highest inhibition of α-glucosidase (54±0.6%) and the mode of α-amylase inhibition was noncompetitive by this honey. Whole extract (23±0.1%) and phenolic extract of Gavan honey presented the maximum inhibition of α-amylase (31.2±0.1%). Conclusion: Honey samples showed antioxidant potentials and anti-diabetic properties by retardation of α-amylase and α-glucosidase.
format	article
author	Mahmoodreza Moein Soheila Moein Fatemeh Farmani Sahere Rozbehan Zahra Sabahi
author_facet	Mahmoodreza Moein Soheila Moein Fatemeh Farmani Sahere Rozbehan Zahra Sabahi
author_sort	Mahmoodreza Moein
title	Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys
title_short	Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys
title_full	Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys
title_fullStr	Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys
title_full_unstemmed	Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys
title_sort	examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some iranian honeys
publisher	Society of Diabetic Nephropathy Prevention
publishDate	2022
url	https://doaj.org/article/e585057b5b4b4804bde6bb85d0912446
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Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys

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