Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury

Weichuan Xiong,1,2 KeJian Qian2 1Department of Critical Care Medicine, The Third Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China; 2Department of Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People&a...

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Autores principales:	Xiong W, Qian K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	acute phase severe traumatic brain injury nutrition low-protein hypocaloric glutamine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e58db540cb1247d6aa79053976f43623
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spelling	oai:doaj.org-article:e58db540cb1247d6aa79053976f436232021-12-02T10:37:31ZLow-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury1178-2021https://doaj.org/article/e58db540cb1247d6aa79053976f436232021-03-01T00:00:00Zhttps://www.dovepress.com/low-protein-hypocaloric-nutrition-with-glutamine-versus-full-feeding-i-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Weichuan Xiong,1,2 KeJian Qian2 1Department of Critical Care Medicine, The Third Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China; 2Department of Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of ChinaCorrespondence: KeJian Qian Email kejianqian@sina.comObjective: To investigate the 28-day mortality, the length of ICU stay, days in the hospital, days of ventilator use, adverse events, and nosocomial infection events of low-protein, hypocaloric nutrition with glutamine in the first 7 days of the intensive care unit (ICU) patients with severe traumatic brain injury (STBI).Patients and Methods: A total of 53 patients diagnosed with STBI enrolled from the third affiliated hospital of Nanchang University (Nanchang, China), from January 2019 to July 2020, were divided into two groups. We performed a randomized prospective controlled trial. The intervention group (n=27) was nutritional supported (intestinal or parenteral) with a caloric capacity of 20– 40% of European Conference on Clinical Nutrition and Metabolism (ESPEN) recommendations; specifically, low-protein intake was 0.5– 0.7g/kg per day (containing the amount of alanyl-glutamine), glutamine was 0.3 g/kg per day, and the intervention treatment lasted for 7 days. The control group (n=26) was nutritionally supported with a caloric capacity of 70– 100% of ESPEN recommendations, and the protein intake was 1.2– 1.7 g/kg per day. The primary endpoint was 28-day mortality. Secondary endpoints were the length of ICU stay, days in the hospital, days of ventilator use, adverse events and nosocomial infection events.Results: There were no differences in baseline characteristics between groups. Survival curve analysis using the Kaplan-Meier method revealed no significant difference in 28-day mortality between the two groups (P=0.31) while adverse events (χ2= 5.853, P=0.016), nosocomial infection rate (χ2 = 4.316, P=0.038), the length of ICU stay (t=− 2.617, P=0.012), hospitalization time (t=− 2.169, P=0.036), and days of ventilator use (t=− 2.144,P=0.037) of patients in the intervention group were significantly lower than those in the control group.Conclusion: Low-protein, hypocaloric nutrition with glutamine did not show different outcomes in 28-day mortality compared to full-feeding nutritional support in the ICU patients with STBI. However, low-protein, hypocaloric nutrition with glutamine could provide a lower need for ICU time, hospitalization time, and ventilator time in the ICU patients with STBI.Keywords: acute phase, severe traumatic brain injury, nutrition, low-protein, hypocaloric, glutamineXiong WQian KDove Medical Pressarticleacute phasesevere traumatic brain injurynutritionlow-proteinhypocaloricglutamineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 703-710 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute phase severe traumatic brain injury nutrition low-protein hypocaloric glutamine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	acute phase severe traumatic brain injury nutrition low-protein hypocaloric glutamine Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xiong W Qian K Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury
description	Weichuan Xiong,1,2 KeJian Qian2 1Department of Critical Care Medicine, The Third Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China; 2Department of Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of ChinaCorrespondence: KeJian Qian Email kejianqian@sina.comObjective: To investigate the 28-day mortality, the length of ICU stay, days in the hospital, days of ventilator use, adverse events, and nosocomial infection events of low-protein, hypocaloric nutrition with glutamine in the first 7 days of the intensive care unit (ICU) patients with severe traumatic brain injury (STBI).Patients and Methods: A total of 53 patients diagnosed with STBI enrolled from the third affiliated hospital of Nanchang University (Nanchang, China), from January 2019 to July 2020, were divided into two groups. We performed a randomized prospective controlled trial. The intervention group (n=27) was nutritional supported (intestinal or parenteral) with a caloric capacity of 20– 40% of European Conference on Clinical Nutrition and Metabolism (ESPEN) recommendations; specifically, low-protein intake was 0.5– 0.7g/kg per day (containing the amount of alanyl-glutamine), glutamine was 0.3 g/kg per day, and the intervention treatment lasted for 7 days. The control group (n=26) was nutritionally supported with a caloric capacity of 70– 100% of ESPEN recommendations, and the protein intake was 1.2– 1.7 g/kg per day. The primary endpoint was 28-day mortality. Secondary endpoints were the length of ICU stay, days in the hospital, days of ventilator use, adverse events and nosocomial infection events.Results: There were no differences in baseline characteristics between groups. Survival curve analysis using the Kaplan-Meier method revealed no significant difference in 28-day mortality between the two groups (P=0.31) while adverse events (χ2= 5.853, P=0.016), nosocomial infection rate (χ2 = 4.316, P=0.038), the length of ICU stay (t=− 2.617, P=0.012), hospitalization time (t=− 2.169, P=0.036), and days of ventilator use (t=− 2.144,P=0.037) of patients in the intervention group were significantly lower than those in the control group.Conclusion: Low-protein, hypocaloric nutrition with glutamine did not show different outcomes in 28-day mortality compared to full-feeding nutritional support in the ICU patients with STBI. However, low-protein, hypocaloric nutrition with glutamine could provide a lower need for ICU time, hospitalization time, and ventilator time in the ICU patients with STBI.Keywords: acute phase, severe traumatic brain injury, nutrition, low-protein, hypocaloric, glutamine
format	article
author	Xiong W Qian K
author_facet	Xiong W Qian K
author_sort	Xiong W
title	Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury
title_short	Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury
title_full	Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury
title_fullStr	Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury
title_full_unstemmed	Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury
title_sort	low-protein, hypocaloric nutrition with glutamine versus full-feeding in the acute phase in icu patients with severe traumatic brain injury
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e58db540cb1247d6aa79053976f43623
work_keys_str_mv	AT xiongw lowproteinhypocaloricnutritionwithglutamineversusfullfeedingintheacutephaseinicupatientswithseveretraumaticbraininjury AT qiank lowproteinhypocaloricnutritionwithglutamineversusfullfeedingintheacutephaseinicupatientswithseveretraumaticbraininjury
_version_	1718396975026536448

Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury

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