Prevalence and detection of low-allele-fraction variants in clinical cancer samples

Prevalence and detection of low-allele-fraction variants in clinical cancer samples

High-throughput sequencing is used to identify somatic variants in cancer patients. Here, the authors perform panel-based profiling of 5095 clinical samples and demonstrate that many clinically-actionable variants have low variant allele fractions, requiring assays with high detection sensitivity.

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Autores principales: Hyun-Tae Shin, Yoon-La Choi, Jae Won Yun, Nayoung K. D. Kim, Sook-Young Kim, Hyo Jeong Jeon, Jae-Yong Nam, Chung Lee, Daeun Ryu, Sang Cheol Kim, Kyunghee Park, Eunjin Lee, Joon Seol Bae, Dae Soon Son, Je-Gun Joung, Jeeyun Lee, Seung Tae Kim, Myung-Ju Ahn, Se-Hoon Lee, Jin Seok Ahn, Woo Yong Lee, Bo Young Oh, Yeon Hee Park, Jeong Eon Lee, Kwang Hyuk Lee, Hee Cheol Kim, Kyoung-Mee Kim, Young-Hyuck Im, Keunchil Park, Peter J. Park, Woong-Yang Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/e58ebe12efcc4384b527ed8e88824f94
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https://doaj.org/article/e58ebe12efcc4384b527ed8e88824f94

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