Prevalence and detection of low-allele-fraction variants in clinical cancer samples

Prevalence and detection of low-allele-fraction variants in clinical cancer samples

High-throughput sequencing is used to identify somatic variants in cancer patients. Here, the authors perform panel-based profiling of 5095 clinical samples and demonstrate that many clinically-actionable variants have low variant allele fractions, requiring assays with high detection sensitivity.

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Autores principales: Hyun-Tae Shin, Yoon-La Choi, Jae Won Yun, Nayoung K. D. Kim, Sook-Young Kim, Hyo Jeong Jeon, Jae-Yong Nam, Chung Lee, Daeun Ryu, Sang Cheol Kim, Kyunghee Park, Eunjin Lee, Joon Seol Bae, Dae Soon Son, Je-Gun Joung, Jeeyun Lee, Seung Tae Kim, Myung-Ju Ahn, Se-Hoon Lee, Jin Seok Ahn, Woo Yong Lee, Bo Young Oh, Yeon Hee Park, Jeong Eon Lee, Kwang Hyuk Lee, Hee Cheol Kim, Kyoung-Mee Kim, Young-Hyuck Im, Keunchil Park, Peter J. Park, Woong-Yang Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e58ebe12efcc4384b527ed8e88824f94
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spelling oai:doaj.org-article:e58ebe12efcc4384b527ed8e88824f942021-12-02T17:01:16ZPrevalence and detection of low-allele-fraction variants in clinical cancer samples10.1038/s41467-017-01470-y2041-1723https://doaj.org/article/e58ebe12efcc4384b527ed8e88824f942017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01470-yhttps://doaj.org/toc/2041-1723High-throughput sequencing is used to identify somatic variants in cancer patients. Here, the authors perform panel-based profiling of 5095 clinical samples and demonstrate that many clinically-actionable variants have low variant allele fractions, requiring assays with high detection sensitivity.Hyun-Tae ShinYoon-La ChoiJae Won YunNayoung K. D. KimSook-Young KimHyo Jeong JeonJae-Yong NamChung LeeDaeun RyuSang Cheol KimKyunghee ParkEunjin LeeJoon Seol BaeDae Soon SonJe-Gun JoungJeeyun LeeSeung Tae KimMyung-Ju AhnSe-Hoon LeeJin Seok AhnWoo Yong LeeBo Young OhYeon Hee ParkJeong Eon LeeKwang Hyuk LeeHee Cheol KimKyoung-Mee KimYoung-Hyuck ImKeunchil ParkPeter J. ParkWoong-Yang ParkNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hyun-Tae Shin
Yoon-La Choi
Jae Won Yun
Nayoung K. D. Kim
Sook-Young Kim
Hyo Jeong Jeon
Jae-Yong Nam
Chung Lee
Daeun Ryu
Sang Cheol Kim
Kyunghee Park
Eunjin Lee
Joon Seol Bae
Dae Soon Son
Je-Gun Joung
Jeeyun Lee
Seung Tae Kim
Myung-Ju Ahn
Se-Hoon Lee
Jin Seok Ahn
Woo Yong Lee
Bo Young Oh
Yeon Hee Park
Jeong Eon Lee
Kwang Hyuk Lee
Hee Cheol Kim
Kyoung-Mee Kim
Young-Hyuck Im
Keunchil Park
Peter J. Park
Woong-Yang Park
Prevalence and detection of low-allele-fraction variants in clinical cancer samples
description High-throughput sequencing is used to identify somatic variants in cancer patients. Here, the authors perform panel-based profiling of 5095 clinical samples and demonstrate that many clinically-actionable variants have low variant allele fractions, requiring assays with high detection sensitivity.
format article
author Hyun-Tae Shin
Yoon-La Choi
Jae Won Yun
Nayoung K. D. Kim
Sook-Young Kim
Hyo Jeong Jeon
Jae-Yong Nam
Chung Lee
Daeun Ryu
Sang Cheol Kim
Kyunghee Park
Eunjin Lee
Joon Seol Bae
Dae Soon Son
Je-Gun Joung
Jeeyun Lee
Seung Tae Kim
Myung-Ju Ahn
Se-Hoon Lee
Jin Seok Ahn
Woo Yong Lee
Bo Young Oh
Yeon Hee Park
Jeong Eon Lee
Kwang Hyuk Lee
Hee Cheol Kim
Kyoung-Mee Kim
Young-Hyuck Im
Keunchil Park
Peter J. Park
Woong-Yang Park
author_facet Hyun-Tae Shin
Yoon-La Choi
Jae Won Yun
Nayoung K. D. Kim
Sook-Young Kim
Hyo Jeong Jeon
Jae-Yong Nam
Chung Lee
Daeun Ryu
Sang Cheol Kim
Kyunghee Park
Eunjin Lee
Joon Seol Bae
Dae Soon Son
Je-Gun Joung
Jeeyun Lee
Seung Tae Kim
Myung-Ju Ahn
Se-Hoon Lee
Jin Seok Ahn
Woo Yong Lee
Bo Young Oh
Yeon Hee Park
Jeong Eon Lee
Kwang Hyuk Lee
Hee Cheol Kim
Kyoung-Mee Kim
Young-Hyuck Im
Keunchil Park
Peter J. Park
Woong-Yang Park
author_sort Hyun-Tae Shin
title Prevalence and detection of low-allele-fraction variants in clinical cancer samples
title_short Prevalence and detection of low-allele-fraction variants in clinical cancer samples
title_full Prevalence and detection of low-allele-fraction variants in clinical cancer samples
title_fullStr Prevalence and detection of low-allele-fraction variants in clinical cancer samples
title_full_unstemmed Prevalence and detection of low-allele-fraction variants in clinical cancer samples
title_sort prevalence and detection of low-allele-fraction variants in clinical cancer samples
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/e58ebe12efcc4384b527ed8e88824f94
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