Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation

Terminal uridyltransferase 7 (TUT7) adds U-tails on diverse RNAs to promote degradation. Here the authors show that TUT7 is induced upon LPS treatment in macrophages and promotes decay of Regnase-1, thereby regulating the expression of a subset of cytokines, including IL-6.

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Autores principales:	Chia-Ching Lin, Yi-Ru Shen, Chi-Chih Chang, Xiang-Yi Guo, Yun-Yun Young, Ting-Yu Lai, I-Shing Yu, Chih-Yuan Lee, Tsung-Hsien Chuang, Hsin-Yue Tsai, Li-Chung Hsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e58f9225379f4a8285ee08d23b8361aa
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spelling	oai:doaj.org-article:e58f9225379f4a8285ee08d23b8361aa2021-12-02T14:34:12ZTerminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation10.1038/s41467-021-24177-72041-1723https://doaj.org/article/e58f9225379f4a8285ee08d23b8361aa2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24177-7https://doaj.org/toc/2041-1723Terminal uridyltransferase 7 (TUT7) adds U-tails on diverse RNAs to promote degradation. Here the authors show that TUT7 is induced upon LPS treatment in macrophages and promotes decay of Regnase-1, thereby regulating the expression of a subset of cytokines, including IL-6.Chia-Ching LinYi-Ru ShenChi-Chih ChangXiang-Yi GuoYun-Yun YoungTing-Yu LaiI-Shing YuChih-Yuan LeeTsung-Hsien ChuangHsin-Yue TsaiLi-Chung HsuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chia-Ching Lin Yi-Ru Shen Chi-Chih Chang Xiang-Yi Guo Yun-Yun Young Ting-Yu Lai I-Shing Yu Chih-Yuan Lee Tsung-Hsien Chuang Hsin-Yue Tsai Li-Chung Hsu Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
description	Terminal uridyltransferase 7 (TUT7) adds U-tails on diverse RNAs to promote degradation. Here the authors show that TUT7 is induced upon LPS treatment in macrophages and promotes decay of Regnase-1, thereby regulating the expression of a subset of cytokines, including IL-6.
format	article
author	Chia-Ching Lin Yi-Ru Shen Chi-Chih Chang Xiang-Yi Guo Yun-Yun Young Ting-Yu Lai I-Shing Yu Chih-Yuan Lee Tsung-Hsien Chuang Hsin-Yue Tsai Li-Chung Hsu
author_facet	Chia-Ching Lin Yi-Ru Shen Chi-Chih Chang Xiang-Yi Guo Yun-Yun Young Ting-Yu Lai I-Shing Yu Chih-Yuan Lee Tsung-Hsien Chuang Hsin-Yue Tsai Li-Chung Hsu
author_sort	Chia-Ching Lin
title	Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
title_short	Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
title_full	Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
title_fullStr	Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
title_full_unstemmed	Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation
title_sort	terminal uridyltransferase 7 regulates tlr4-triggered inflammation by controlling regnase-1 mrna uridylation and degradation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e58f9225379f4a8285ee08d23b8361aa
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Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation

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