Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive metastatic disease characterized by an immunosuppressive microenvironment. Here the authors show that a subset of P2RX1-negative neutrophils with immunosuppressive properties accumulate in PDAC metastatic liver tissues and promote tumor...

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Main Authors: Xu Wang, Li-Peng Hu, Wei-Ting Qin, Qin Yang, De-Yu Chen, Qing Li, Kai-Xia Zhou, Pei-Qi Huang, Chun-Jie Xu, Jun Li, Lin-Li Yao, Ya-Hui Wang, Guang-Ang Tian, Jian-Yu Yang, Min-Wei Yang, De-Jun Liu, Yong-Wei Sun, Shu-Heng Jiang, Xue-Li Zhang, Zhi-Gang Zhang
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/e5c9f48dd02248afa64c33593ecd5868
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https://doaj.org/article/e5c9f48dd02248afa64c33593ecd5868

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