Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy

Abstract Injuries to flexor tendons can be complicated by fibrotic adhesions, which severely impair the function of the hand. Adhesions have been associated with TGF-β1, which causes upregulation of PAI-1, a master suppressor of protease activity, including matrix metalloproteinases (MMP). In the pr...

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Autores principales: Margaret A. T. Freeberg, Youssef M. Farhat, Anas Easa, Jacob G. Kallenbach, Dominic W. Malcolm, Mark R. Buckley, Danielle S. W. Benoit, Hani A. Awad
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/e5cdfd5cb21341d4a50f60bcc3be2d10
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