Combining Mutations That Inhibit Two Distinct Steps of the ATP Hydrolysis Cycle Restores Wild-Type Function in the Lipopolysaccharide Transporter and Shows that ATP Binding Triggers Transport
ABSTRACT ATP-binding cassette (ABC) transporters constitute a large family of proteins present in all domains of life. They are powered by dynamic ATPases that harness energy from binding and hydrolyzing ATP through a cycle that involves the closing and reopening of their two ATP-binding domains. Th...
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Main Authors: | Brent W. Simpson, Karanbir S. Pahil, Tristan W. Owens, Emily A. Lundstedt, Rebecca M. Davis, Daniel Kahne, Natividad Ruiz |
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Format: | article |
Language: | EN |
Published: |
American Society for Microbiology
2019
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Subjects: | |
Online Access: | https://doaj.org/article/e5f9ae4be9c9430f83be36fa788bf4ff |
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