Sensing intracellular calcium ions using a manganese-based MRI contrast agent

There are only few MRI-compatible calcium reporters and they are limited to measuring extracellular calcium levels. Here the authors develop and validate a cell-permeable, manganese-based paramagnetic MRI contrast agent that enables monitoring intracellular calcium signals in vivo in the rat brain.

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Bibliographic Details
Main Authors:	Ali Barandov, Benjamin B. Bartelle, Catherine G. Williamson, Emily S. Loucks, Stephen J. Lippard, Alan Jasanoff
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/e5faf82e358e48b88a58d6f635d5f18c
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spelling	oai:doaj.org-article:e5faf82e358e48b88a58d6f635d5f18c2021-12-02T17:01:37ZSensing intracellular calcium ions using a manganese-based MRI contrast agent10.1038/s41467-019-08558-72041-1723https://doaj.org/article/e5faf82e358e48b88a58d6f635d5f18c2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08558-7https://doaj.org/toc/2041-1723There are only few MRI-compatible calcium reporters and they are limited to measuring extracellular calcium levels. Here the authors develop and validate a cell-permeable, manganese-based paramagnetic MRI contrast agent that enables monitoring intracellular calcium signals in vivo in the rat brain.Ali BarandovBenjamin B. BartelleCatherine G. WilliamsonEmily S. LoucksStephen J. LippardAlan JasanoffNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ali Barandov Benjamin B. Bartelle Catherine G. Williamson Emily S. Loucks Stephen J. Lippard Alan Jasanoff Sensing intracellular calcium ions using a manganese-based MRI contrast agent
description	There are only few MRI-compatible calcium reporters and they are limited to measuring extracellular calcium levels. Here the authors develop and validate a cell-permeable, manganese-based paramagnetic MRI contrast agent that enables monitoring intracellular calcium signals in vivo in the rat brain.
format	article
author	Ali Barandov Benjamin B. Bartelle Catherine G. Williamson Emily S. Loucks Stephen J. Lippard Alan Jasanoff
author_facet	Ali Barandov Benjamin B. Bartelle Catherine G. Williamson Emily S. Loucks Stephen J. Lippard Alan Jasanoff
author_sort	Ali Barandov
title	Sensing intracellular calcium ions using a manganese-based MRI contrast agent
title_short	Sensing intracellular calcium ions using a manganese-based MRI contrast agent
title_full	Sensing intracellular calcium ions using a manganese-based MRI contrast agent
title_fullStr	Sensing intracellular calcium ions using a manganese-based MRI contrast agent
title_full_unstemmed	Sensing intracellular calcium ions using a manganese-based MRI contrast agent
title_sort	sensing intracellular calcium ions using a manganese-based mri contrast agent
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e5faf82e358e48b88a58d6f635d5f18c
work_keys_str_mv	AT alibarandov sensingintracellularcalciumionsusingamanganesebasedmricontrastagent AT benjaminbbartelle sensingintracellularcalciumionsusingamanganesebasedmricontrastagent AT catherinegwilliamson sensingintracellularcalciumionsusingamanganesebasedmricontrastagent AT emilysloucks sensingintracellularcalciumionsusingamanganesebasedmricontrastagent AT stephenjlippard sensingintracellularcalciumionsusingamanganesebasedmricontrastagent AT alanjasanoff sensingintracellularcalciumionsusingamanganesebasedmricontrastagent
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Sensing intracellular calcium ions using a manganese-based MRI contrast agent

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