Cell shape information is transduced through tension-independent mechanisms

Cell shape information is transduced through tension-independent mechanisms

It is not known whether the shape of a cell can regulate cellular phenotype independently. Here, the authors show that culturing kidney podocytes or smooth muscle cells on 3-D biomimetic surfaces results in phenotypic changes and that cell shape is sensed by integrin β3 in a tension-independent mann...

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Autores principales: Amit Ron, Evren U. Azeloglu, Rhodora C. Calizo, Mufeng Hu, Smiti Bhattacharya, Yibang Chen, Gomathi Jayaraman, Sunwoo Lee, Susana R. Neves-Zaph, Hong Li, Ronald E. Gordon, John C. He, James C. Hone, Ravi Iyengar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/e603071ebf0d4ed3b0ea421e96a6072e
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https://doaj.org/article/e603071ebf0d4ed3b0ea421e96a6072e

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