Cell shape information is transduced through tension-independent mechanisms

It is not known whether the shape of a cell can regulate cellular phenotype independently. Here, the authors show that culturing kidney podocytes or smooth muscle cells on 3-D biomimetic surfaces results in phenotypic changes and that cell shape is sensed by integrin β3 in a tension-independent mann...

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Autores principales:	Amit Ron, Evren U. Azeloglu, Rhodora C. Calizo, Mufeng Hu, Smiti Bhattacharya, Yibang Chen, Gomathi Jayaraman, Sunwoo Lee, Susana R. Neves-Zaph, Hong Li, Ronald E. Gordon, John C. He, James C. Hone, Ravi Iyengar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e603071ebf0d4ed3b0ea421e96a6072e
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spelling	oai:doaj.org-article:e603071ebf0d4ed3b0ea421e96a6072e2021-12-02T14:42:39ZCell shape information is transduced through tension-independent mechanisms10.1038/s41467-017-02218-42041-1723https://doaj.org/article/e603071ebf0d4ed3b0ea421e96a6072e2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02218-4https://doaj.org/toc/2041-1723It is not known whether the shape of a cell can regulate cellular phenotype independently. Here, the authors show that culturing kidney podocytes or smooth muscle cells on 3-D biomimetic surfaces results in phenotypic changes and that cell shape is sensed by integrin β3 in a tension-independent manner.Amit RonEvren U. AzelogluRhodora C. CalizoMufeng HuSmiti BhattacharyaYibang ChenGomathi JayaramanSunwoo LeeSusana R. Neves-ZaphHong LiRonald E. GordonJohn C. HeJames C. HoneRavi IyengarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amit Ron Evren U. Azeloglu Rhodora C. Calizo Mufeng Hu Smiti Bhattacharya Yibang Chen Gomathi Jayaraman Sunwoo Lee Susana R. Neves-Zaph Hong Li Ronald E. Gordon John C. He James C. Hone Ravi Iyengar Cell shape information is transduced through tension-independent mechanisms
description	It is not known whether the shape of a cell can regulate cellular phenotype independently. Here, the authors show that culturing kidney podocytes or smooth muscle cells on 3-D biomimetic surfaces results in phenotypic changes and that cell shape is sensed by integrin β3 in a tension-independent manner.
format	article
author	Amit Ron Evren U. Azeloglu Rhodora C. Calizo Mufeng Hu Smiti Bhattacharya Yibang Chen Gomathi Jayaraman Sunwoo Lee Susana R. Neves-Zaph Hong Li Ronald E. Gordon John C. He James C. Hone Ravi Iyengar
author_facet	Amit Ron Evren U. Azeloglu Rhodora C. Calizo Mufeng Hu Smiti Bhattacharya Yibang Chen Gomathi Jayaraman Sunwoo Lee Susana R. Neves-Zaph Hong Li Ronald E. Gordon John C. He James C. Hone Ravi Iyengar
author_sort	Amit Ron
title	Cell shape information is transduced through tension-independent mechanisms
title_short	Cell shape information is transduced through tension-independent mechanisms
title_full	Cell shape information is transduced through tension-independent mechanisms
title_fullStr	Cell shape information is transduced through tension-independent mechanisms
title_full_unstemmed	Cell shape information is transduced through tension-independent mechanisms
title_sort	cell shape information is transduced through tension-independent mechanisms
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e603071ebf0d4ed3b0ea421e96a6072e
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Cell shape information is transduced through tension-independent mechanisms

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