Cell shape information is transduced through tension-independent mechanisms
It is not known whether the shape of a cell can regulate cellular phenotype independently. Here, the authors show that culturing kidney podocytes or smooth muscle cells on 3-D biomimetic surfaces results in phenotypic changes and that cell shape is sensed by integrin β3 in a tension-independent mann...
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Main Authors: | Amit Ron, Evren U. Azeloglu, Rhodora C. Calizo, Mufeng Hu, Smiti Bhattacharya, Yibang Chen, Gomathi Jayaraman, Sunwoo Lee, Susana R. Neves-Zaph, Hong Li, Ronald E. Gordon, John C. He, James C. Hone, Ravi Iyengar |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
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Subjects: | |
Online Access: | https://doaj.org/article/e603071ebf0d4ed3b0ea421e96a6072e |
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