S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis
Abstract Autism Spectrum Disorders (ASD) are caused by a combination of genetic predisposition and nongenetic factors. Among the nongenetic factors, maternal immune system activation and zinc deficiency have been proposed. Intriguingly, as a genetic factor, copy-number variations in S100B, a pro-inf...
Guardado en:
Autores principales: | Eleonora Daini, Simone Hagmeyer, Chiara A. De Benedictis, Joana S. Cristóvão, Martina Bodria, Aisling M. Ross, Andrea Raab, Tobias M. Boeckers, Joerg Feldmann, Cláudio M. Gomes, Michele Zoli, Antonietta Vilella, Andreas M. Grabrucker |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Publishing Group
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/e66884e838aa463eb9316b5178485c50 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice
por: Anne-Kathrin Lutz, et al.
Publicado: (2021) -
Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications
por: Jan Philipp Delling, et al.
Publicado: (2021) -
Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
por: Saša Peter, et al.
Publicado: (2016) -
A recurrent SHANK3 frameshift variant in Autism Spectrum Disorder
por: Livia O. Loureiro, et al.
Publicado: (2021) -
Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage.
por: Teresa Lorenzi, et al.
Publicado: (2012)