S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis

S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis

Abstract Autism Spectrum Disorders (ASD) are caused by a combination of genetic predisposition and nongenetic factors. Among the nongenetic factors, maternal immune system activation and zinc deficiency have been proposed. Intriguingly, as a genetic factor, copy-number variations in S100B, a pro-inf...

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Autores principales: Eleonora Daini, Simone Hagmeyer, Chiara A. De Benedictis, Joana S. Cristóvão, Martina Bodria, Aisling M. Ross, Andrea Raab, Tobias M. Boeckers, Joerg Feldmann, Cláudio M. Gomes, Michele Zoli, Antonietta Vilella, Andreas M. Grabrucker
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Acceso en línea:https://doaj.org/article/e66884e838aa463eb9316b5178485c50
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