Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk.

Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk.

Polymorphisms in and around the Cholesteryl Ester Transfer Protein (CETP) gene have been associated with HDL levels, risk for coronary artery disease (CAD), and response to therapy. The mechanism of action of these polymorphisms has yet to be defined. We used mRNA allelic expression and splice isofo...

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Auteurs principaux: Audrey C Papp, Julia K Pinsonneault, Danxin Wang, Leslie C Newman, Yan Gong, Julie A Johnson, Carl J Pepine, Meena Kumari, Aroon D Hingorani, Philippa J Talmud, Sonia Shah, Steve E Humphries, Wolfgang Sadee
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/e6846031eab348b5a7925fc31e4fa446
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Internet

https://doaj.org/article/e6846031eab348b5a7925fc31e4fa446

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