Genome-Wide siRNA Screen Identifies Complementary Signaling Pathways Involved in <italic toggle="yes">Listeria</italic> Infection and Reveals Different Actin Nucleation Mechanisms during <italic toggle="yes">Listeria</italic> Cell Invasion and Actin Comet Tail Formation

Genome-Wide siRNA Screen Identifies Complementary Signaling Pathways Involved in <italic toggle="yes">Listeria</italic> Infection and Reveals Different Actin Nucleation Mechanisms during <italic toggle="yes">Listeria</italic> Cell Invasion and Actin Comet Tail Formation

ABSTRACT Listeria monocytogenes enters nonphagocytic cells by a receptor-mediated mechanism that is dependent on a clathrin-based molecular machinery and actin rearrangements. Bacterial intra- and intercellular movements are also actin dependent and rely on the actin nucleating Arp2/3 complex, which...

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Autores principales: Andreas Kühbacher, Mario Emmenlauer, Pauli Rämo, Natasha Kafai, Christoph Dehio, Pascale Cossart, Javier Pizarro-Cerdá
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/e684d7ac5e7c46c8bae6ac0cdf53c382
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