Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation
DNA methylation is critically involved in X chromosome inactivation (XCI) and dosage compensation, yet some X-chromosomal genes escape XCI. Here, Lujik et al. identify three autosomal genetic loci that associate with differential DNA methylation near genes that variably escape XCI in females.
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Nature Portfolio
2018
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oai:doaj.org-article:e69790735e37408d91bf21a46c5fc5b62021-12-02T15:33:36ZAutosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation10.1038/s41467-018-05714-32041-1723https://doaj.org/article/e69790735e37408d91bf21a46c5fc5b62018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05714-3https://doaj.org/toc/2041-1723DNA methylation is critically involved in X chromosome inactivation (XCI) and dosage compensation, yet some X-chromosomal genes escape XCI. Here, Lujik et al. identify three autosomal genetic loci that associate with differential DNA methylation near genes that variably escape XCI in females.René LuijkHaoyu WuCavin K Ward-CavinessEilis HannonElena Carnero-MontoroJosine L. MinPooja MandaviyaMartina Müller-NurasyidHailiang MeiSilvere M. van der MaarelBIOS ConsortiumCaroline ReltonJonathan MillMelanie WaldenbergerJordana T. BellRick JansenAlexandra ZhernakovaLude FrankePeter A. C. ‘t HoenDorret I. BoomsmaCornelia M. van DuijnMarleen M. J. van GreevenbroekJan H. VeldinkCisca WijmengaJoyce van MeursLucia DaxingerP. Eline SlagboomErik W. van ZwetBastiaan T. HeijmansNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q René Luijk Haoyu Wu Cavin K Ward-Caviness Eilis Hannon Elena Carnero-Montoro Josine L. Min Pooja Mandaviya Martina Müller-Nurasyid Hailiang Mei Silvere M. van der Maarel BIOS Consortium Caroline Relton Jonathan Mill Melanie Waldenberger Jordana T. Bell Rick Jansen Alexandra Zhernakova Lude Franke Peter A. C. ‘t Hoen Dorret I. Boomsma Cornelia M. van Duijn Marleen M. J. van Greevenbroek Jan H. Veldink Cisca Wijmenga Joyce van Meurs Lucia Daxinger P. Eline Slagboom Erik W. van Zwet Bastiaan T. Heijmans Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation |
| description |
DNA methylation is critically involved in X chromosome inactivation (XCI) and dosage compensation, yet some X-chromosomal genes escape XCI. Here, Lujik et al. identify three autosomal genetic loci that associate with differential DNA methylation near genes that variably escape XCI in females. |
| format |
article |
| author |
René Luijk Haoyu Wu Cavin K Ward-Caviness Eilis Hannon Elena Carnero-Montoro Josine L. Min Pooja Mandaviya Martina Müller-Nurasyid Hailiang Mei Silvere M. van der Maarel BIOS Consortium Caroline Relton Jonathan Mill Melanie Waldenberger Jordana T. Bell Rick Jansen Alexandra Zhernakova Lude Franke Peter A. C. ‘t Hoen Dorret I. Boomsma Cornelia M. van Duijn Marleen M. J. van Greevenbroek Jan H. Veldink Cisca Wijmenga Joyce van Meurs Lucia Daxinger P. Eline Slagboom Erik W. van Zwet Bastiaan T. Heijmans |
| author_facet |
René Luijk Haoyu Wu Cavin K Ward-Caviness Eilis Hannon Elena Carnero-Montoro Josine L. Min Pooja Mandaviya Martina Müller-Nurasyid Hailiang Mei Silvere M. van der Maarel BIOS Consortium Caroline Relton Jonathan Mill Melanie Waldenberger Jordana T. Bell Rick Jansen Alexandra Zhernakova Lude Franke Peter A. C. ‘t Hoen Dorret I. Boomsma Cornelia M. van Duijn Marleen M. J. van Greevenbroek Jan H. Veldink Cisca Wijmenga Joyce van Meurs Lucia Daxinger P. Eline Slagboom Erik W. van Zwet Bastiaan T. Heijmans |
| author_sort |
René Luijk |
| title |
Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation |
| title_short |
Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation |
| title_full |
Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation |
| title_fullStr |
Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation |
| title_full_unstemmed |
Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation |
| title_sort |
autosomal genetic variation is associated with dna methylation in regions variably escaping x-chromosome inactivation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/e69790735e37408d91bf21a46c5fc5b6 |
| work_keys_str_mv |
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