Improved genetic prediction of complex traits from individual-level data or summary statistics

Existing genetic prediction tools typically assume that genetic variants contribute equally towards the phenotype. The authors develop eight prediction tools that allow the user to specify the heritability model, and show that these tools enable substantially improved prediction of complex traits.

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Auteurs principaux: Qianqian Zhang, Florian Privé, Bjarni Vilhjálmsson, Doug Speed
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/e6a0de6c6c764b68a43c1149c37ff7d3
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Résumé:Existing genetic prediction tools typically assume that genetic variants contribute equally towards the phenotype. The authors develop eight prediction tools that allow the user to specify the heritability model, and show that these tools enable substantially improved prediction of complex traits.