AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

Basal cell carcinoma (BCC) cells with increased nuclear myocardin-related transcription factor (nMRTF) levels are resistant to Smoothened inhibitors, however how MRTF activity is regulated is still elusive. Here, the authors identify a LYPD3+/TACSTD2+/LY6D+ BCC subpopulation of resistant BCC cells w...

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Main Authors: Catherine D. Yao, Daniel Haensel, Sadhana Gaddam, Tiffany Patel, Scott X. Atwood, Kavita Y. Sarin, Ramon J. Whitson, Siegen McKellar, Gautam Shankar, Sumaira Aasi, Kerri Rieger, Anthony E. Oro
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/e6b18a583afe4ea5bde3d4d2f73b777e
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