Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation

Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation

Maria Feola et al., elucidate the compensatory role of pleckstrin-2 in ineffective erythropoiesis in β-thalassemic mice by reducing cofilin-mediated apoptosis and enhancing enucleation by activating RacGTPases. These findings could support future therapeutic interventions.

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Auteurs principaux: Maria Feola, Andrea Zamperone, Daniel Moskop, Huiyong Chen, Carla Casu, Dechen Lama, Julie Di Martino, Mansour Djedaini, Luena Papa, Marc Ruiz Martinez, Tenzin Choesang, Jose Javier Bravo-Cordero, Matthew MacKay, Paul Zumbo, Nathan Brinkman, Charles S. Abrams, Stefano Rivella, Shilpa Hattangadi, Christopher E. Mason, Ronald Hoffman, Peng Ji, Antonia Follenzi, Yelena Z. Ginzburg
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/e6bba204b45a41b58086958c1edd4975
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Internet

https://doaj.org/article/e6bba204b45a41b58086958c1edd4975

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