Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation

Maria Feola et al., elucidate the compensatory role of pleckstrin-2 in ineffective erythropoiesis in β-thalassemic mice by reducing cofilin-mediated apoptosis and enhancing enucleation by activating RacGTPases. These findings could support future therapeutic interventions.

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria Feola, Andrea Zamperone, Daniel Moskop, Huiyong Chen, Carla Casu, Dechen Lama, Julie Di Martino, Mansour Djedaini, Luena Papa, Marc Ruiz Martinez, Tenzin Choesang, Jose Javier Bravo-Cordero, Matthew MacKay, Paul Zumbo, Nathan Brinkman, Charles S. Abrams, Stefano Rivella, Shilpa Hattangadi, Christopher E. Mason, Ronald Hoffman, Peng Ji, Antonia Follenzi, Yelena Z. Ginzburg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e6bba204b45a41b58086958c1edd4975
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e6bba204b45a41b58086958c1edd4975
record_format	dspace
spelling	oai:doaj.org-article:e6bba204b45a41b58086958c1edd49752021-12-02T15:37:57ZPleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation10.1038/s42003-021-02046-92399-3642https://doaj.org/article/e6bba204b45a41b58086958c1edd49752021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02046-9https://doaj.org/toc/2399-3642Maria Feola et al., elucidate the compensatory role of pleckstrin-2 in ineffective erythropoiesis in β-thalassemic mice by reducing cofilin-mediated apoptosis and enhancing enucleation by activating RacGTPases. These findings could support future therapeutic interventions.Maria FeolaAndrea ZamperoneDaniel MoskopHuiyong ChenCarla CasuDechen LamaJulie Di MartinoMansour DjedainiLuena PapaMarc Ruiz MartinezTenzin ChoesangJose Javier Bravo-CorderoMatthew MacKayPaul ZumboNathan BrinkmanCharles S. AbramsStefano RivellaShilpa HattangadiChristopher E. MasonRonald HoffmanPeng JiAntonia FollenziYelena Z. GinzburgNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Maria Feola Andrea Zamperone Daniel Moskop Huiyong Chen Carla Casu Dechen Lama Julie Di Martino Mansour Djedaini Luena Papa Marc Ruiz Martinez Tenzin Choesang Jose Javier Bravo-Cordero Matthew MacKay Paul Zumbo Nathan Brinkman Charles S. Abrams Stefano Rivella Shilpa Hattangadi Christopher E. Mason Ronald Hoffman Peng Ji Antonia Follenzi Yelena Z. Ginzburg Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation
description	Maria Feola et al., elucidate the compensatory role of pleckstrin-2 in ineffective erythropoiesis in β-thalassemic mice by reducing cofilin-mediated apoptosis and enhancing enucleation by activating RacGTPases. These findings could support future therapeutic interventions.
format	article
author	Maria Feola Andrea Zamperone Daniel Moskop Huiyong Chen Carla Casu Dechen Lama Julie Di Martino Mansour Djedaini Luena Papa Marc Ruiz Martinez Tenzin Choesang Jose Javier Bravo-Cordero Matthew MacKay Paul Zumbo Nathan Brinkman Charles S. Abrams Stefano Rivella Shilpa Hattangadi Christopher E. Mason Ronald Hoffman Peng Ji Antonia Follenzi Yelena Z. Ginzburg
author_facet	Maria Feola Andrea Zamperone Daniel Moskop Huiyong Chen Carla Casu Dechen Lama Julie Di Martino Mansour Djedaini Luena Papa Marc Ruiz Martinez Tenzin Choesang Jose Javier Bravo-Cordero Matthew MacKay Paul Zumbo Nathan Brinkman Charles S. Abrams Stefano Rivella Shilpa Hattangadi Christopher E. Mason Ronald Hoffman Peng Ji Antonia Follenzi Yelena Z. Ginzburg
author_sort	Maria Feola
title	Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation
title_short	Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation
title_full	Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation
title_fullStr	Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation
title_full_unstemmed	Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation
title_sort	pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6bba204b45a41b58086958c1edd4975
work_keys_str_mv	AT mariafeola pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT andreazamperone pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT danielmoskop pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT huiyongchen pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT carlacasu pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT dechenlama pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT juliedimartino pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT mansourdjedaini pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT luenapapa pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT marcruizmartinez pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT tenzinchoesang pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT josejavierbravocordero pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT matthewmackay pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT paulzumbo pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT nathanbrinkman pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT charlessabrams pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT stefanorivella pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT shilpahattangadi pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT christopheremason pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT ronaldhoffman pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT pengji pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT antoniafollenzi pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation AT yelenazginzburg pleckstrin2isessentialforerythropoiesisinbthalassemicmicereducingapoptosisandenhancingenucleation
_version_	1718386206450909184

Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation

Ejemplares similares