The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Chimeric antigen receptors (CARs) are effective tools for directing T cell killing of tumors, but may cause adverse side effects. Here the authors show that coupling of antigen-recognition and CD3-binding in a modular format induces more efficient anti-tumour responses but reduced toxicity when comp...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Christopher W. Helsen, Joanne A. Hammill, Vivian W. C. Lau, Kenneth A. Mwawasi, Arya Afsahi, Ksenia Bezverbnaya, Lisa Newhook, Danielle L. Hayes, Craig Aarts, Bojana Bojovic, Galina F. Denisova, Jacek M. Kwiecien, Ian Brain, Heather Derocher, Katy Milne, Brad H. Nelson, Jonathan L. Bramson
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/e6ef202d9e6344acbce6ee90ed3c483d
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/e6ef202d9e6344acbce6ee90ed3c483d

Documents similaires