The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Chimeric antigen receptors (CARs) are effective tools for directing T cell killing of tumors, but may cause adverse side effects. Here the authors show that coupling of antigen-recognition and CD3-binding in a modular format induces more efficient anti-tumour responses but reduced toxicity when comp...

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Autores principales:	Christopher W. Helsen, Joanne A. Hammill, Vivian W. C. Lau, Kenneth A. Mwawasi, Arya Afsahi, Ksenia Bezverbnaya, Lisa Newhook, Danielle L. Hayes, Craig Aarts, Bojana Bojovic, Galina F. Denisova, Jacek M. Kwiecien, Ian Brain, Heather Derocher, Katy Milne, Brad H. Nelson, Jonathan L. Bramson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6ef202d9e6344acbce6ee90ed3c483d
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spelling	oai:doaj.org-article:e6ef202d9e6344acbce6ee90ed3c483d2021-12-02T15:34:05ZThe chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity10.1038/s41467-018-05395-y2041-1723https://doaj.org/article/e6ef202d9e6344acbce6ee90ed3c483d2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05395-yhttps://doaj.org/toc/2041-1723Chimeric antigen receptors (CARs) are effective tools for directing T cell killing of tumors, but may cause adverse side effects. Here the authors show that coupling of antigen-recognition and CD3-binding in a modular format induces more efficient anti-tumour responses but reduced toxicity when compared with current CARs.Christopher W. HelsenJoanne A. HammillVivian W. C. LauKenneth A. MwawasiArya AfsahiKsenia BezverbnayaLisa NewhookDanielle L. HayesCraig AartsBojana BojovicGalina F. DenisovaJacek M. KwiecienIan BrainHeather DerocherKaty MilneBrad H. NelsonJonathan L. BramsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher W. Helsen Joanne A. Hammill Vivian W. C. Lau Kenneth A. Mwawasi Arya Afsahi Ksenia Bezverbnaya Lisa Newhook Danielle L. Hayes Craig Aarts Bojana Bojovic Galina F. Denisova Jacek M. Kwiecien Ian Brain Heather Derocher Katy Milne Brad H. Nelson Jonathan L. Bramson The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
description	Chimeric antigen receptors (CARs) are effective tools for directing T cell killing of tumors, but may cause adverse side effects. Here the authors show that coupling of antigen-recognition and CD3-binding in a modular format induces more efficient anti-tumour responses but reduced toxicity when compared with current CARs.
format	article
author	Christopher W. Helsen Joanne A. Hammill Vivian W. C. Lau Kenneth A. Mwawasi Arya Afsahi Ksenia Bezverbnaya Lisa Newhook Danielle L. Hayes Craig Aarts Bojana Bojovic Galina F. Denisova Jacek M. Kwiecien Ian Brain Heather Derocher Katy Milne Brad H. Nelson Jonathan L. Bramson
author_facet	Christopher W. Helsen Joanne A. Hammill Vivian W. C. Lau Kenneth A. Mwawasi Arya Afsahi Ksenia Bezverbnaya Lisa Newhook Danielle L. Hayes Craig Aarts Bojana Bojovic Galina F. Denisova Jacek M. Kwiecien Ian Brain Heather Derocher Katy Milne Brad H. Nelson Jonathan L. Bramson
author_sort	Christopher W. Helsen
title	The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
title_short	The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
title_full	The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
title_fullStr	The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
title_full_unstemmed	The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
title_sort	chimeric tac receptor co-opts the t cell receptor yielding robust anti-tumor activity without toxicity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e6ef202d9e6344acbce6ee90ed3c483d
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The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

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