Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice

By introducing a ribosomal ambiguity mutation into mice, Moore et al. establish an in-vivo model to investigate how age-related diseases are related to decreasing accuracy in protein synthesis. Their findings potentially offer new insights into the pathological changes observed in age-related diseas...

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Bibliographic Details
Main Authors: James Moore, Rashid Akbergenov, Martina Nigri, Patricia Isnard-Petit, Amandine Grimm, Petra Seebeck, Lisa Restelli, Stephan Frank, Anne Eckert, Kader Thiam, David P. Wolfer, Dimitri Shcherbakov, Erik C. Böttger
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/e6f25dccdabb450fa330934a966a5a73
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