Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice

By introducing a ribosomal ambiguity mutation into mice, Moore et al. establish an in-vivo model to investigate how age-related diseases are related to decreasing accuracy in protein synthesis. Their findings potentially offer new insights into the pathological changes observed in age-related diseas...

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Autores principales:	James Moore, Rashid Akbergenov, Martina Nigri, Patricia Isnard-Petit, Amandine Grimm, Petra Seebeck, Lisa Restelli, Stephan Frank, Anne Eckert, Kader Thiam, David P. Wolfer, Dimitri Shcherbakov, Erik C. Böttger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e6f25dccdabb450fa330934a966a5a73
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spelling	oai:doaj.org-article:e6f25dccdabb450fa330934a966a5a732021-12-02T15:02:51ZRandom errors in protein synthesis activate an age-dependent program of muscle atrophy in mice10.1038/s42003-021-02204-z2399-3642https://doaj.org/article/e6f25dccdabb450fa330934a966a5a732021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02204-zhttps://doaj.org/toc/2399-3642By introducing a ribosomal ambiguity mutation into mice, Moore et al. establish an in-vivo model to investigate how age-related diseases are related to decreasing accuracy in protein synthesis. Their findings potentially offer new insights into the pathological changes observed in age-related diseases, such as muscle atrophyJames MooreRashid AkbergenovMartina NigriPatricia Isnard-PetitAmandine GrimmPetra SeebeckLisa RestelliStephan FrankAnne EckertKader ThiamDavid P. WolferDimitri ShcherbakovErik C. BöttgerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 James Moore Rashid Akbergenov Martina Nigri Patricia Isnard-Petit Amandine Grimm Petra Seebeck Lisa Restelli Stephan Frank Anne Eckert Kader Thiam David P. Wolfer Dimitri Shcherbakov Erik C. Böttger Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice
description	By introducing a ribosomal ambiguity mutation into mice, Moore et al. establish an in-vivo model to investigate how age-related diseases are related to decreasing accuracy in protein synthesis. Their findings potentially offer new insights into the pathological changes observed in age-related diseases, such as muscle atrophy
format	article
author	James Moore Rashid Akbergenov Martina Nigri Patricia Isnard-Petit Amandine Grimm Petra Seebeck Lisa Restelli Stephan Frank Anne Eckert Kader Thiam David P. Wolfer Dimitri Shcherbakov Erik C. Böttger
author_facet	James Moore Rashid Akbergenov Martina Nigri Patricia Isnard-Petit Amandine Grimm Petra Seebeck Lisa Restelli Stephan Frank Anne Eckert Kader Thiam David P. Wolfer Dimitri Shcherbakov Erik C. Böttger
author_sort	James Moore
title	Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice
title_short	Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice
title_full	Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice
title_fullStr	Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice
title_full_unstemmed	Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice
title_sort	random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e6f25dccdabb450fa330934a966a5a73
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Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice

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