Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice
By introducing a ribosomal ambiguity mutation into mice, Moore et al. establish an in-vivo model to investigate how age-related diseases are related to decreasing accuracy in protein synthesis. Their findings potentially offer new insights into the pathological changes observed in age-related diseas...
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Autores principales: | James Moore, Rashid Akbergenov, Martina Nigri, Patricia Isnard-Petit, Amandine Grimm, Petra Seebeck, Lisa Restelli, Stephan Frank, Anne Eckert, Kader Thiam, David P. Wolfer, Dimitri Shcherbakov, Erik C. Böttger |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/e6f25dccdabb450fa330934a966a5a73 |
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