Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice
By introducing a ribosomal ambiguity mutation into mice, Moore et al. establish an in-vivo model to investigate how age-related diseases are related to decreasing accuracy in protein synthesis. Their findings potentially offer new insights into the pathological changes observed in age-related diseas...
Saved in:
Main Authors: | James Moore, Rashid Akbergenov, Martina Nigri, Patricia Isnard-Petit, Amandine Grimm, Petra Seebeck, Lisa Restelli, Stephan Frank, Anne Eckert, Kader Thiam, David P. Wolfer, Dimitri Shcherbakov, Erik C. Böttger |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
|
Subjects: | |
Online Access: | https://doaj.org/article/e6f25dccdabb450fa330934a966a5a73 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Silencing of the ER and Integrative Stress Responses in the Liver of Mice with Error-Prone Translation
by: James Moore, et al.
Published: (2021) -
ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function
by: Adrián Cortés Sanchón, et al.
Published: (2021) -
Identification and Evaluation of Improved 4′-<italic toggle="yes">O</italic>-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics
by: Stefan Duscha, et al.
Published: (2014) -
Thyroid Hormone Action in Muscle Atrophy
by: Maria Angela De Stefano, et al.
Published: (2021) -
Hormonal Approach for Postmenopausal Vulvovaginal Atrophy
by: Ana Paula Ferreira Costa, et al.
Published: (2021)