NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

Thymocytes are screened by two processes, termed positive and negative selections, which are permissive only for immature thymocytes with intermediate avidity to the selecting ligands. Here the authors show that the nuclear receptor NCoR1 suppresses Bim1 to inhibit negative selection and promote thy...

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Autores principales:	Jianrong Wang, Nanhai He, Na Zhang, Dexian Quan, Shuo Zhang, Caroline Zhang, Ruth T. Yu, Annette R. Atkins, Ruihong Zhu, Chunhui Yang, Ying Cui, Christopher Liddle, Michael Downes, Hui Xiao, Ye Zheng, Johan Auwerx, Ronald M. Evans, Qibin Leng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e700911c66cc46a6bbd123fe83a42ce0
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spelling	oai:doaj.org-article:e700911c66cc46a6bbd123fe83a42ce02021-12-02T17:01:19ZNCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection10.1038/s41467-017-00931-82041-1723https://doaj.org/article/e700911c66cc46a6bbd123fe83a42ce02017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00931-8https://doaj.org/toc/2041-1723Thymocytes are screened by two processes, termed positive and negative selections, which are permissive only for immature thymocytes with intermediate avidity to the selecting ligands. Here the authors show that the nuclear receptor NCoR1 suppresses Bim1 to inhibit negative selection and promote thymocyte survival.Jianrong WangNanhai HeNa ZhangDexian QuanShuo ZhangCaroline ZhangRuth T. YuAnnette R. AtkinsRuihong ZhuChunhui YangYing CuiChristopher LiddleMichael DownesHui XiaoYe ZhengJohan AuwerxRonald M. EvansQibin LengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianrong Wang Nanhai He Na Zhang Dexian Quan Shuo Zhang Caroline Zhang Ruth T. Yu Annette R. Atkins Ruihong Zhu Chunhui Yang Ying Cui Christopher Liddle Michael Downes Hui Xiao Ye Zheng Johan Auwerx Ronald M. Evans Qibin Leng NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
description	Thymocytes are screened by two processes, termed positive and negative selections, which are permissive only for immature thymocytes with intermediate avidity to the selecting ligands. Here the authors show that the nuclear receptor NCoR1 suppresses Bim1 to inhibit negative selection and promote thymocyte survival.
format	article
author	Jianrong Wang Nanhai He Na Zhang Dexian Quan Shuo Zhang Caroline Zhang Ruth T. Yu Annette R. Atkins Ruihong Zhu Chunhui Yang Ying Cui Christopher Liddle Michael Downes Hui Xiao Ye Zheng Johan Auwerx Ronald M. Evans Qibin Leng
author_facet	Jianrong Wang Nanhai He Na Zhang Dexian Quan Shuo Zhang Caroline Zhang Ruth T. Yu Annette R. Atkins Ruihong Zhu Chunhui Yang Ying Cui Christopher Liddle Michael Downes Hui Xiao Ye Zheng Johan Auwerx Ronald M. Evans Qibin Leng
author_sort	Jianrong Wang
title	NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
title_short	NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
title_full	NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
title_fullStr	NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
title_full_unstemmed	NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
title_sort	ncor1 restrains thymic negative selection by repressing bim expression to spare thymocytes undergoing positive selection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e700911c66cc46a6bbd123fe83a42ce0
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NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

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