Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system
G-protein-coupled receptors are a large and diverse group of eukaryotic membrane receptors. Here the authors couple GPCRs to dCas9 to link extracellular sensing to genome regulation.
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Nature Portfolio
2017
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oai:doaj.org-article:e70108db447c4b069358555aee209a1d2021-12-02T14:41:08ZEngineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system10.1038/s41467-017-02075-12041-1723https://doaj.org/article/e70108db447c4b069358555aee209a1d2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02075-1https://doaj.org/toc/2041-1723G-protein-coupled receptors are a large and diverse group of eukaryotic membrane receptors. Here the authors couple GPCRs to dCas9 to link extracellular sensing to genome regulation.Nathan H. KipnissP. C. Dave P. DingalTimothy R. AbbottYuchen GaoHaifeng WangAntonia A. DominguezLouai LabaniehLei S. QiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
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Science Q |
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Science Q Nathan H. Kipniss P. C. Dave P. Dingal Timothy R. Abbott Yuchen Gao Haifeng Wang Antonia A. Dominguez Louai Labanieh Lei S. Qi Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system |
description |
G-protein-coupled receptors are a large and diverse group of eukaryotic membrane receptors. Here the authors couple GPCRs to dCas9 to link extracellular sensing to genome regulation. |
format |
article |
author |
Nathan H. Kipniss P. C. Dave P. Dingal Timothy R. Abbott Yuchen Gao Haifeng Wang Antonia A. Dominguez Louai Labanieh Lei S. Qi |
author_facet |
Nathan H. Kipniss P. C. Dave P. Dingal Timothy R. Abbott Yuchen Gao Haifeng Wang Antonia A. Dominguez Louai Labanieh Lei S. Qi |
author_sort |
Nathan H. Kipniss |
title |
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system |
title_short |
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system |
title_full |
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system |
title_fullStr |
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system |
title_full_unstemmed |
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system |
title_sort |
engineering cell sensing and responses using a gpcr-coupled crispr-cas system |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/e70108db447c4b069358555aee209a1d |
work_keys_str_mv |
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