Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway

Biosynthetic gene clusters (BGCs) make small molecules with fitness-enhancing activities that drive BGC evolution. Here, the authors show that synthetic biology can leverage bioactivity to achieve continuous evolution of an antibiotic BGC in the lab and improve antibiotic production in a new host.

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Detalles Bibliográficos
Autores principales: Chad W. Johnston, Ahmed H. Badran, James J. Collins
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e70d674f16914a20ad1827cab565434c
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