Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway

Biosynthetic gene clusters (BGCs) make small molecules with fitness-enhancing activities that drive BGC evolution. Here, the authors show that synthetic biology can leverage bioactivity to achieve continuous evolution of an antibiotic BGC in the lab and improve antibiotic production in a new host.

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Detalles Bibliográficos
Autores principales:	Chad W. Johnston, Ahmed H. Badran, James J. Collins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e70d674f16914a20ad1827cab565434c
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spelling	oai:doaj.org-article:e70d674f16914a20ad1827cab565434c2021-12-02T17:08:46ZContinuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway10.1038/s41467-020-18018-22041-1723https://doaj.org/article/e70d674f16914a20ad1827cab565434c2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18018-2https://doaj.org/toc/2041-1723Biosynthetic gene clusters (BGCs) make small molecules with fitness-enhancing activities that drive BGC evolution. Here, the authors show that synthetic biology can leverage bioactivity to achieve continuous evolution of an antibiotic BGC in the lab and improve antibiotic production in a new host.Chad W. JohnstonAhmed H. BadranJames J. CollinsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chad W. Johnston Ahmed H. Badran James J. Collins Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway
description	Biosynthetic gene clusters (BGCs) make small molecules with fitness-enhancing activities that drive BGC evolution. Here, the authors show that synthetic biology can leverage bioactivity to achieve continuous evolution of an antibiotic BGC in the lab and improve antibiotic production in a new host.
format	article
author	Chad W. Johnston Ahmed H. Badran James J. Collins
author_facet	Chad W. Johnston Ahmed H. Badran James J. Collins
author_sort	Chad W. Johnston
title	Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway
title_short	Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway
title_full	Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway
title_fullStr	Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway
title_full_unstemmed	Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway
title_sort	continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e70d674f16914a20ad1827cab565434c
work_keys_str_mv	AT chadwjohnston continuousbioactivitydependentevolutionofanantibioticbiosyntheticpathway AT ahmedhbadran continuousbioactivitydependentevolutionofanantibioticbiosyntheticpathway AT jamesjcollins continuousbioactivitydependentevolutionofanantibioticbiosyntheticpathway
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Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway

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