Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways.

The p21-activated protein kinases (Paks) have been implicated in the regulation of smooth muscle contractility, but the physiologic effects of Pak activation on airway reactivity in vivo are unknown. A mouse model with a genetic deletion of Pak1 (Pak1(-/-)) was used to determine the role of Pak in t...

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Autores principales: Wyn C Hoover, Wenwu Zhang, Zhidong Xue, Huanling Gao, Jonathan Chernoff, D Wade Clapp, Susan J Gunst, Robert S Tepper
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/e70f8d114cec47d19054a3fefe910f9b
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