A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi

Many pathogens manipulate ubiquitin-mediated signaling to evade host cell defense. Here, the authors characterize the structure and enzymatic activity of a deubiquitylase domain from the causative pathogen of scrub typhus, providing evidence for a distinct mechanism of ubiquitin chain selectivity.

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Auteurs principaux: Jason M. Berk, Christopher Lim, Judith A. Ronau, Apala Chaudhuri, Hongli Chen, John F. Beckmann, J. Patrick Loria, Yong Xiong, Mark Hochstrasser
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/e72272f032014c63830d698e467f3709
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