MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically
Cancer cells frequently harbour genetic aberrations that protect them from programmed cell death. Here, the authors show in non-small cell lung cancer that the anti-apoptotic gene MCL-1 is subject to copy number gains and that deletion of MCL-1 reduces tumour formation.
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Nature Portfolio
2020
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oai:doaj.org-article:e72e961b8ad54302879663e878f7c62b2021-12-02T14:54:51ZMCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically10.1038/s41467-020-18372-12041-1723https://doaj.org/article/e72e961b8ad54302879663e878f7c62b2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18372-1https://doaj.org/toc/2041-1723Cancer cells frequently harbour genetic aberrations that protect them from programmed cell death. Here, the authors show in non-small cell lung cancer that the anti-apoptotic gene MCL-1 is subject to copy number gains and that deletion of MCL-1 reduces tumour formation.Enkhtsetseg MunkhbaatarMichelle DietzenDeepti AgrawalMartina AntonMoritz JesinghausMelanie BoxbergNicole PfarrPidassa BidolaSebastian UhrigUlrike HöckendorfAnna-Lena MeinhardtAdam WahidaIrina HeidRickmer BrarenRitu MishraArne WarthThomas MuleyPatrina S. P. PohXin WangStefan FröhlingKatja SteigerJulia Slotta-HuspeninaMartijn van GriensvenFranz PfeifferSebastian LangeRoland RadMagda SpellaGeorgios T. StathopoulosJürgen RulandFlorian BassermannWilko WeichertAndreas StrasserCaterina BrancaMathias HeikenwalderCharles SwantonNicholas McGranahanPhilipp J. JostNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Enkhtsetseg Munkhbaatar Michelle Dietzen Deepti Agrawal Martina Anton Moritz Jesinghaus Melanie Boxberg Nicole Pfarr Pidassa Bidola Sebastian Uhrig Ulrike Höckendorf Anna-Lena Meinhardt Adam Wahida Irina Heid Rickmer Braren Ritu Mishra Arne Warth Thomas Muley Patrina S. P. Poh Xin Wang Stefan Fröhling Katja Steiger Julia Slotta-Huspenina Martijn van Griensven Franz Pfeiffer Sebastian Lange Roland Rad Magda Spella Georgios T. Stathopoulos Jürgen Ruland Florian Bassermann Wilko Weichert Andreas Strasser Caterina Branca Mathias Heikenwalder Charles Swanton Nicholas McGranahan Philipp J. Jost MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically |
| description |
Cancer cells frequently harbour genetic aberrations that protect them from programmed cell death. Here, the authors show in non-small cell lung cancer that the anti-apoptotic gene MCL-1 is subject to copy number gains and that deletion of MCL-1 reduces tumour formation. |
| format |
article |
| author |
Enkhtsetseg Munkhbaatar Michelle Dietzen Deepti Agrawal Martina Anton Moritz Jesinghaus Melanie Boxberg Nicole Pfarr Pidassa Bidola Sebastian Uhrig Ulrike Höckendorf Anna-Lena Meinhardt Adam Wahida Irina Heid Rickmer Braren Ritu Mishra Arne Warth Thomas Muley Patrina S. P. Poh Xin Wang Stefan Fröhling Katja Steiger Julia Slotta-Huspenina Martijn van Griensven Franz Pfeiffer Sebastian Lange Roland Rad Magda Spella Georgios T. Stathopoulos Jürgen Ruland Florian Bassermann Wilko Weichert Andreas Strasser Caterina Branca Mathias Heikenwalder Charles Swanton Nicholas McGranahan Philipp J. Jost |
| author_facet |
Enkhtsetseg Munkhbaatar Michelle Dietzen Deepti Agrawal Martina Anton Moritz Jesinghaus Melanie Boxberg Nicole Pfarr Pidassa Bidola Sebastian Uhrig Ulrike Höckendorf Anna-Lena Meinhardt Adam Wahida Irina Heid Rickmer Braren Ritu Mishra Arne Warth Thomas Muley Patrina S. P. Poh Xin Wang Stefan Fröhling Katja Steiger Julia Slotta-Huspenina Martijn van Griensven Franz Pfeiffer Sebastian Lange Roland Rad Magda Spella Georgios T. Stathopoulos Jürgen Ruland Florian Bassermann Wilko Weichert Andreas Strasser Caterina Branca Mathias Heikenwalder Charles Swanton Nicholas McGranahan Philipp J. Jost |
| author_sort |
Enkhtsetseg Munkhbaatar |
| title |
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically |
| title_short |
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically |
| title_full |
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically |
| title_fullStr |
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically |
| title_full_unstemmed |
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically |
| title_sort |
mcl-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/e72e961b8ad54302879663e878f7c62b |
| work_keys_str_mv |
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1718389419610734592 |