The presence of extra chromosomes leads to genomic instability

One of the hallmarks of cancer cells is aneuploidy, however the molecular effects are poorly understood. Here the authors show that trisomic and tetrasomic cells display increased genomic instability and reduced levels of the helicase MCM2-7.

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Autores principales: Verena Passerini, Efrat Ozeri-Galai, Mirjam S. de Pagter, Neysan Donnelly, Sarah Schmalbrock, Wigard P. Kloosterman, Batsheva Kerem, Zuzana Storchová
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/e73b828e409d4bfbb86d27e03daef072
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