The presence of extra chromosomes leads to genomic instability

One of the hallmarks of cancer cells is aneuploidy, however the molecular effects are poorly understood. Here the authors show that trisomic and tetrasomic cells display increased genomic instability and reduced levels of the helicase MCM2-7.

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Autores principales:	Verena Passerini, Efrat Ozeri-Galai, Mirjam S. de Pagter, Neysan Donnelly, Sarah Schmalbrock, Wigard P. Kloosterman, Batsheva Kerem, Zuzana Storchová
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e73b828e409d4bfbb86d27e03daef072
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spelling	oai:doaj.org-article:e73b828e409d4bfbb86d27e03daef0722021-12-02T14:39:13ZThe presence of extra chromosomes leads to genomic instability10.1038/ncomms107542041-1723https://doaj.org/article/e73b828e409d4bfbb86d27e03daef0722016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10754https://doaj.org/toc/2041-1723One of the hallmarks of cancer cells is aneuploidy, however the molecular effects are poorly understood. Here the authors show that trisomic and tetrasomic cells display increased genomic instability and reduced levels of the helicase MCM2-7.Verena PasseriniEfrat Ozeri-GalaiMirjam S. de PagterNeysan DonnellySarah SchmalbrockWigard P. KloostermanBatsheva KeremZuzana StorchováNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Verena Passerini Efrat Ozeri-Galai Mirjam S. de Pagter Neysan Donnelly Sarah Schmalbrock Wigard P. Kloosterman Batsheva Kerem Zuzana Storchová The presence of extra chromosomes leads to genomic instability
description	One of the hallmarks of cancer cells is aneuploidy, however the molecular effects are poorly understood. Here the authors show that trisomic and tetrasomic cells display increased genomic instability and reduced levels of the helicase MCM2-7.
format	article
author	Verena Passerini Efrat Ozeri-Galai Mirjam S. de Pagter Neysan Donnelly Sarah Schmalbrock Wigard P. Kloosterman Batsheva Kerem Zuzana Storchová
author_facet	Verena Passerini Efrat Ozeri-Galai Mirjam S. de Pagter Neysan Donnelly Sarah Schmalbrock Wigard P. Kloosterman Batsheva Kerem Zuzana Storchová
author_sort	Verena Passerini
title	The presence of extra chromosomes leads to genomic instability
title_short	The presence of extra chromosomes leads to genomic instability
title_full	The presence of extra chromosomes leads to genomic instability
title_fullStr	The presence of extra chromosomes leads to genomic instability
title_full_unstemmed	The presence of extra chromosomes leads to genomic instability
title_sort	presence of extra chromosomes leads to genomic instability
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e73b828e409d4bfbb86d27e03daef072
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The presence of extra chromosomes leads to genomic instability

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