Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.

Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pa...

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Autores principales: Lukasz Kedzierski, Edmond M Linossi, Tatiana B Kolesnik, E Bridie Day, Nicola L Bird, Benjamin T Kile, Gabrielle T Belz, Donald Metcalf, Nicos A Nicola, Katherine Kedzierska, Sandra E Nicholson
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Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/e74a61e58a7f4bfba5811da5416a7bf4
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spelling oai:doaj.org-article:e74a61e58a7f4bfba5811da5416a7bf42021-11-18T06:06:36ZSuppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.1553-73661553-737410.1371/journal.ppat.1004134https://doaj.org/article/e74a61e58a7f4bfba5811da5416a7bf42014-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24809749/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pathogenic H1N1 influenza virus (PR8) and are hypersusceptible to infection with the less virulent H3N2 (X31) strain. In SOCS4-deficient animals, this led to substantially greater weight loss, dysregulated pro-inflammatory cytokine and chemokine production in the lungs and delayed viral clearance. This was associated with impaired trafficking of influenza-specific CD8 T cells to the site of infection and linked to defects in T cell receptor activation. These results demonstrate that SOCS4 is a critical regulator of anti-viral immunity.Lukasz KedzierskiEdmond M LinossiTatiana B KolesnikE Bridie DayNicola L BirdBenjamin T KileGabrielle T BelzDonald MetcalfNicos A NicolaKatherine KedzierskaSandra E NicholsonPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 10, Iss 5, p e1004134 (2014)
institution DOAJ
collection DOAJ
language EN
topic Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
spellingShingle Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Lukasz Kedzierski
Edmond M Linossi
Tatiana B Kolesnik
E Bridie Day
Nicola L Bird
Benjamin T Kile
Gabrielle T Belz
Donald Metcalf
Nicos A Nicola
Katherine Kedzierska
Sandra E Nicholson
Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
description Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pathogenic H1N1 influenza virus (PR8) and are hypersusceptible to infection with the less virulent H3N2 (X31) strain. In SOCS4-deficient animals, this led to substantially greater weight loss, dysregulated pro-inflammatory cytokine and chemokine production in the lungs and delayed viral clearance. This was associated with impaired trafficking of influenza-specific CD8 T cells to the site of infection and linked to defects in T cell receptor activation. These results demonstrate that SOCS4 is a critical regulator of anti-viral immunity.
format article
author Lukasz Kedzierski
Edmond M Linossi
Tatiana B Kolesnik
E Bridie Day
Nicola L Bird
Benjamin T Kile
Gabrielle T Belz
Donald Metcalf
Nicos A Nicola
Katherine Kedzierska
Sandra E Nicholson
author_facet Lukasz Kedzierski
Edmond M Linossi
Tatiana B Kolesnik
E Bridie Day
Nicola L Bird
Benjamin T Kile
Gabrielle T Belz
Donald Metcalf
Nicos A Nicola
Katherine Kedzierska
Sandra E Nicholson
author_sort Lukasz Kedzierski
title Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
title_short Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
title_full Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
title_fullStr Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
title_full_unstemmed Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
title_sort suppressor of cytokine signaling 4 (socs4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/e74a61e58a7f4bfba5811da5416a7bf4
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