Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.

Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pa...

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Autores principales:	Lukasz Kedzierski, Edmond M Linossi, Tatiana B Kolesnik, E Bridie Day, Nicola L Bird, Benjamin T Kile, Gabrielle T Belz, Donald Metcalf, Nicos A Nicola, Katherine Kedzierska, Sandra E Nicholson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e74a61e58a7f4bfba5811da5416a7bf4
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spelling	oai:doaj.org-article:e74a61e58a7f4bfba5811da5416a7bf42021-11-18T06:06:36ZSuppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.1553-73661553-737410.1371/journal.ppat.1004134https://doaj.org/article/e74a61e58a7f4bfba5811da5416a7bf42014-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24809749/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pathogenic H1N1 influenza virus (PR8) and are hypersusceptible to infection with the less virulent H3N2 (X31) strain. In SOCS4-deficient animals, this led to substantially greater weight loss, dysregulated pro-inflammatory cytokine and chemokine production in the lungs and delayed viral clearance. This was associated with impaired trafficking of influenza-specific CD8 T cells to the site of infection and linked to defects in T cell receptor activation. These results demonstrate that SOCS4 is a critical regulator of anti-viral immunity.Lukasz KedzierskiEdmond M LinossiTatiana B KolesnikE Bridie DayNicola L BirdBenjamin T KileGabrielle T BelzDonald MetcalfNicos A NicolaKatherine KedzierskaSandra E NicholsonPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 10, Iss 5, p e1004134 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Lukasz Kedzierski Edmond M Linossi Tatiana B Kolesnik E Bridie Day Nicola L Bird Benjamin T Kile Gabrielle T Belz Donald Metcalf Nicos A Nicola Katherine Kedzierska Sandra E Nicholson Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
description	Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pathogenic H1N1 influenza virus (PR8) and are hypersusceptible to infection with the less virulent H3N2 (X31) strain. In SOCS4-deficient animals, this led to substantially greater weight loss, dysregulated pro-inflammatory cytokine and chemokine production in the lungs and delayed viral clearance. This was associated with impaired trafficking of influenza-specific CD8 T cells to the site of infection and linked to defects in T cell receptor activation. These results demonstrate that SOCS4 is a critical regulator of anti-viral immunity.
format	article
author	Lukasz Kedzierski Edmond M Linossi Tatiana B Kolesnik E Bridie Day Nicola L Bird Benjamin T Kile Gabrielle T Belz Donald Metcalf Nicos A Nicola Katherine Kedzierska Sandra E Nicholson
author_facet	Lukasz Kedzierski Edmond M Linossi Tatiana B Kolesnik E Bridie Day Nicola L Bird Benjamin T Kile Gabrielle T Belz Donald Metcalf Nicos A Nicola Katherine Kedzierska Sandra E Nicholson
author_sort	Lukasz Kedzierski
title	Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
title_short	Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
title_full	Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
title_fullStr	Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
title_full_unstemmed	Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
title_sort	suppressor of cytokine signaling 4 (socs4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/e74a61e58a7f4bfba5811da5416a7bf4
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Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.

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