Identification and Evaluation of Improved 4′-<italic toggle="yes">O</italic>-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics

Identification and Evaluation of Improved 4′-<italic toggle="yes">O</italic>-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics

ABSTRACT The emerging epidemic of drug resistance places the development of efficacious and safe antibiotics in the spotlight of current research. Here, we report the design of next-generation aminoglycosides. Discovery efforts were driven by rational synthesis focusing on 4′ alkylations of the amin...

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Autores principales: Stefan Duscha, Heithem Boukari, Dimitri Shcherbakov, Sumantha Salian, Sandrina Silva, Ann Kendall, Takayuki Kato, Rashid Akbergenov, Deborah Perez-Fernandez, Bruno Bernet, Swapna Vaddi, Pia Thommes, Jochen Schacht, David Crich, Andrea Vasella, Erik C. Böttger
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/e75ab41e6d784ecd8f204ed86b0f4019
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