Response of Merkel cell polyomavirus-positive merkel cell carcinoma xenografts to a survivin inhibitor.

Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with high mortality. Merkel cell polyomavirus (MCV), discovered in 2008, is associated with ~80% of MCC. The MCV large tumor (LT) oncoprotein upregulates the cellular oncoprotein survivin through its conserved retinoblastoma prot...

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Autores principales: Lindsay R Dresang, Anna Guastafierro, Reety Arora, Daniel Normolle, Yuan Chang, Patrick S Moore
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/e7909d6eac544daa993c3a34efd7e948
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