HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning

Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.

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Auteurs principaux: Alessandra Ferrari, Raffaella Longo, Erika Fiorino, Rui Silva, Nico Mitro, Gaia Cermenati, Federica Gilardi, Béatrice Desvergne, Annapaola Andolfo, Cinzia Magagnotti, Donatella Caruso, Emma De Fabiani, Scott W. Hiebert, Maurizio Crestani
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Q
Accès en ligne:https://doaj.org/article/e79e6f94830242d2a35e5f6ab7dac919
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